Glutamine synthetase of pseudomonads: some biochemical and physicochemical properties.

Biochemical and molecular analysis of glutamine synthetase gene in brassica napus L.

The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad.

Nicotinamide-adenine dinucleotide (NAD+) synthetases catalyze the last step in NAD+ metabolism in the de novo, import, and salvage pathways that originate from tryptophan (or aspartic acid), nicotinic acid, and nicotinamide, respectively, and converge on nicotinic acid mononucleotide. NAD+ synthetase converts nicotinic acid adenine dinucleotide to NAD+ via an adenylylated intermediate. All of t...

Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells.

In certain lines of hepatoma tissue-culture cells, the extracellular glutamine concentration regulates the specific activity of glutamine synthetase. By quantifying the radioactivity in immunoprecipitated glutamine synthetase on polyacrylamide gels, we found that the rate of degradation, but not of synthesis, of glutamine synthetase is a sensitive function of extracellular glutamine. The activi...

Fundamentals of Chemotherapy

The book is well produced by photo-offset reproduction from typescript and contains a large number of figures, illustrations and diagrams. There is a comprehensive collection of references which is complete until 1972. The work is divided into two parts, the first dealing with enzymes involved in glutamats-glutamine interconversion and the second discussing those enzymes that use the amide nitr...

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver.

Glutamine synthetase activity in a cytosol extract of liver was inhibited non-competitively by Mn2+ ions. The apparent Ki for Mn2" in the presence of phosphate was 8 micro M. Inhibition of glutamine synthetase by intracellular Mn2+ may contribute to the very low rates of glutamine synthesis observed in perfused liver and isolated hepatocytes.